AntiPlatelet theraPy stratEgy followiNg Left Atrial appenDAGe closurE

Summary

The APPENDAGE study is a phase 4 multicentre randomized opened clinical trial comparing 2 different antithrombotic strategies following left atrial appendage closure (LAAC) in patients with non valvular atrial fibrillation (AF). The primary objective of the study is to evaluate the efficacy of Aspirin versus Aspirin + Clopidogrel after LAAC by comparing the occurrence of ischemic lesions on cerebrovascular magnetic resonance imaging (MRI) studies.

Timeline

Start

2022-10-03

Primary completion

2027-05-03

Completion

2027-05-03

Publications

• Results Cochet H, Iriart X, Sridi S, Camaioni C, Corneloup O, Montaudon M, Laurent F, Selmi W, Renou P, Jalal Z, Thambo JB. Left atrial appendage patency and device-related thrombus after percutaneous left atrial appendage occlusion: a computed tomography study. Eur Heart J Cardiovasc Imaging. 2018 Dec 1;19(12):1351-1361. doi: 10.1093/ehjci/jey010.

Drugs

Indications