drugset / Trial / NCT04803747
A Trial of a Hospital Policy of Tranexamic Acid Use to Reduce Transfusion in Major Non-cardiac Surgery
Phase 4
Completed
8421 enrolled
University of Manitoba
Canadian Institutes of Health Research (CIHR) · collabHealth Sciences Centre Foundation, Manitoba · collabThe Ottawa Hospital · collab
RandomizedCrossoverTriple-blindTreatment
Summary
A Phase IV trial of a hospital policy of Tranexamic acid to reduce transfusion in major non-cardiac surgery.
Timeline
- Start
- 2022-02-16
- Primary completion
- 2024-03-05
- Completion
- 2024-06-03
Publications
- Houston BL, McIsaac DI, Breau RH, Kanji S, Greenstreet P, Andrews M, Avramescu S, Bagry HS, Balshaw R, Daya J, Duncan K, Harle CC, Jacobsohn E, Kerelska T, Pitz M, Komenda P, McIsaac S, Ramsay T, Saha T, Tinmouth A, Recio A, Szoke D, Tenenbein M, Slagerman S, Solvason D, Talarico R, Fergusson DA, Zarychanski R. Hospital Policy of Tranexamic Acid to Reduce Transfusion in Major Noncardiac Surgery. N Engl J Med. 2026 Jun 25;394(24):2419-2428. doi: 10.1056/NEJMoa2515820. Epub 2026 Jun 10.
- Houston BL, McIsaac DI, Breau RH, Andrews M, Avramescu S, Bagry H, Balshaw RF, Daya J, Duncan K, Harle C, Jacobsohn E, Kerelska T, McIsaac S, Ramsay T, Saha T, Perelman I, Recio A, Solvason D, Szoke D, Tenenbein M, Fergusson DA, Zarychanski R. Hospital policy of tranexamic acid to reduce transfusion in major non-cardiac surgery (TRACTION): protocol for a phase IV randomised controlled trial. BMJ Open. 2024 Jun 3;14(6):e084847. doi: 10.1136/bmjopen-2024-084847.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Tranexamic Acid | Small molecule | 1 g | Intravenous |
| Comparator | Tranexamic Acid | Small molecule | 2 g | Intravenous |
Indications
No indication recorded.