drugset

drugset / Trial / NCT04853797

Effect of Ivabradine on Levcromakalim-Induced Symptoms in Individuals With Migraine Without Aura (ILIM)

NCT04853797 ↗

Completed 37 enrolled Danish Headache Center

RandomizedCrossoverQuadruple-blindOther

Summary

This study aims to explore the effect of Ivabradine on Levcromakalim-induced migraine in individuals with migraine without aura.

Timeline

Start: 2021-05-11
Primary completion: 2025-07-06
Completion: 2025-07-06

Publications

Zhuang ZA, Thuraiaiyah J, Kokoti L, Moreno RD, Gozalov E, Hakimzadeh Z, Al-Karagholi MA, Clement A, Kristensen DM, Abdulla J, Christensen SL, Ashina M. Migraine induced by vascular KATP channel activation is independent of HCN channel activity: A randomised controlled trial with translational validation. Cephalalgia. 2026 Apr;46(4):3331024261431770. doi: 10.1177/03331024261431770. Epub 2026 Apr 3.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Ivabradine	Small molecule	15 mg	Oral
Comparator	Levcromakalim	Small molecule	1 mg	Intravenous

Indications