Dapagliflozin on Volume Vascular Outcomes.

Summary

The purpose of the DAPA-VOLVO trial is to investigate the effects of Dapagliflozin on top of recommended standard therapy on volume status and vascular function in clinically stable de novo or chronic heart failure patients after hospitalization because of an acute decompensated heart failure event.

Timeline

Start

2021-02-15

Primary completion

2024-09-26

Completion

2024-10-28

Publications

• Bitos K, Laptseva N, Haider T, Rossi VA, Nagele MP, Barthelmes J, Ruschitzka F, Sudano I, Flammer AJ. Effects of dapagliflozin on blood volume status and vascular outcomes in clinically stabilized heart failure patients after an acute decompensated heart failure event (DAPA-VOLVO study): Protocol of a double-blind randomized controlled clinical trial. PLoS One. 2025 Jul 2;20(7):e0325668. doi: 10.1371/journal.pone.0325668. eCollection 2025.

Drugs

Indications