Pre-emptive Treatments in Lupus Nephritis Patients With Serological Reactivation

Summary

The optimal management of asymptomatic serological reactivation (ASR) in lupus nephritis (LN) patients remained undefined. This project aims to investigate the impact of pre-emptive treatment on disease relapse in LN patients who experienced ASR.

Timeline

Start

2016-04-21

Primary completion

2022-03-31

Completion

2022-03-31

Publications

• Yap DYH, Chan SCW, Wong PYH, Wong S, Zhang D, Yung S, Lo JMW, Lau CS, Tang C, Chan TM. A prospective multicenter randomized controlled trial pre-emptive increase in immunosuppression for asymptomatic serological reactivation in patients with lupus nephritis in clinical remission. Kidney Int. 2026 Jul;110(1):245-254. doi: 10.1016/j.kint.2026.02.037. Epub 2026 Mar 27.

Drugs

Indications