Prevention of Persistent Pain With LidocAine iNfusions in Breast Cancer Surgery (PLAN)

Phase 3 Recruiting 1602 enrolled University Health Network, Toronto Canadian Institutes of Health Research (CIHR) · collab

RandomizedParallel-groupQuadruple-blindPrevention

Summary

Phase III, international multicentre, parallel group, blinded, 1:1 randomized controlled trial to determine the effect of an intraoperative intravenous lidocaine infusion on reducing the development of persistent pain 3-months after breast cancer surgery.

Timeline

Start: 2021-09-22
Primary completion: 2026-04-30
Completion: 2026-11-01

Publications

Khan JS, Gilron I, Devereaux PJ, Clarke H, Ayach N, Tomlinson G, Quan ML, Ladha KS, Choi S, Munro A, Brull R, Lim DW, Avramescu S, Richebe P, Hodgson N, Paul J, McIsaac DI, Derzi S, Zbitnew GL, Easson AM, Siddiqui NT, Miles SJ, Karkouti K; PLAN Trial Investigators. Prevention of persistent pain with lidocaine infusions in breast cancer surgery (PLAN): study protocol for a multicenter randomized controlled trial. Trials. 2024 May 22;25(1):337. doi: 10.1186/s13063-024-08151-4.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Lidocaine	Other / unclassified	2 mg/kg	Intravenous

Prevention of Persistent Pain With LidocAine iNfusions in Breast Cancer Surgery (PLAN)

Summary

Timeline

Publications

Drugs

Indications