Obstetric Liposomal Bupivacaine Via Surgical Transversus Abdominis Plane Block for Post Cesarean Pain Control

Phase 4 Completed 60 enrolled University of Wisconsin, Madison Meriter Foundation · collab

RandomizedParallel-groupSingle-blindTreatment

Summary

This study seeks to identify whether the addition of liposomal bupivacaine to regular bupivacaine and saline administered via surgical transversus abdominis plane (TAP) block will reduce the cumulative opioid dose in the first 48 hours after cesarean. 60 women scheduled for cesarean at Unity-Point Health Meriter Hospital in Madison, Wisconsin will be enrolled and can be expect to be on study for up to 6 weeks post-partum.

Timeline

Start: 2021-10-11
Primary completion: 2022-08-31
Completion: 2022-10-13

Outcome

Missed primary endpoint

paper compared with 8 morphine milligram equivalents (interquartile range, 0-40) among participants allocated to the control group (P=.236). PMID 38154599 ↗

Publications

Antony KM, McDonald RC, Gaston L, Hetzel S, Li Z. Surgical transversus abdominis plane block with liposomal bupivacaine at cesarean: a pilot randomized trial. Am J Obstet Gynecol MFM. 2024 Feb;6(2):101273. doi: 10.1016/j.ajogmf.2023.101273. Epub 2023 Dec 26.

Drugs

Evaluation	Drug	Modality	Dose	Route
Background	Bupivacaine	Other / unclassified	20 ml	Other
Background	Bupivacaine	Other / unclassified	0.25 %	Other
Background	Bupivacaine	Other / unclassified	30 ml	Other