Insulin Stimulated Vasodilation in Patients With Type 2 Diabetes

Unknown 22 enrolled University of Southern Denmark The University of Texas at Arlington · collab

Non-randomizedParallel-groupOpen-labelBasic science

Summary

This study evaluates the role of endothelin in insulin stimulated vasodilation and glucose uptake. The subjects will complete an hyperinsulinemic euglycemic clamp with and without blockade of the endothelin receptors.

Timeline

Start: 2018-05-01
Primary completion: 2021-07-30
Completion: 2021-07-30

Publications

Young BE, Padilla J, Finsen SH, Fadel PJ, Mortensen SP. Role of Endothelin-1 Receptors in Limiting Leg Blood Flow and Glucose Uptake During Hyperinsulinemia in Type 2 Diabetes. Endocrinology. 2022 Mar 1;163(3):bqac008. doi: 10.1210/endocr/bqac008.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	BQ-123	Peptide	25 unknown	Other
Subject	BQ-788	Unknown	25 unknown	—
Background	Insulin	Protein / enzyme biologic	—	Other

Insulin Stimulated Vasodilation in Patients With Type 2 Diabetes

Summary

Timeline

Publications

Drugs

Indications