Nebivolol 0.5, 1.0, or Timolol 0.5 Suspension Compared to Timolol 0.5 Solution to Treat Glaucoma/Ocular Hypertension
Summary
The purpose of this study is to evaluate the safety (in the eye and throughout the body) and effectiveness of nebivolol (0.5 and 1 percent) and timolol (0.5 percent) eye drop suspensions. These eye drops will be compared to timolol 0.5 percent eye drop solution in participants with open angle glaucoma (the most common type of glaucoma) or high eye pressure (ocular hypertension).
Timeline
- Start
- 2021-04-15
- Primary completion
- 2022-03-31
- Completion
- 2022-04-29
Outcome
Missed primary endpoint
registry analysis (non-inferiority test); Nebivolol Ophthalmic Suspension 1 Percent vs Timolol Ophthalmic Solution 0.5 Percent; Timepoints with Mean IOP < 1.5 mm Hg 0 NCT04910100 ↗
registry analysis (non-inferiority test); Nebivolol Ophthalmic Suspension 0.5 Percent vs Timolol Ophthalmic Solution 0.5 Percent; Timepoints with Mean IOP < 1.5 mm Hg 0 NCT04910100 ↗
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Nebivolol | Other / unclassified | 0.5 % | Topical |
| Subject | Nebivolol | Other / unclassified | 1 % | Topical |
| Subject | Timolol | Other / unclassified | 0.5 % | Topical |