drugset / Trial / NCT04939662

Olaparib and Bevacizumab in Relapsed Small Cell Lung Cancer Subjects

NCT04939662 ↗

NaSingle-groupOpen-labelTreatment

Summary

This study is a single arm, multi-centre phase II study of olaparib and bevacizumab combination therapy in subjects with relapsed small cell lung cancer (SCLC) as a second or third line (systemic) therapy. Subjects will receive olaparib and bevacizumab combination therapy. The arm is composed of 28 subjects. Olaparib 300 mg bid per os every 12 hours administered each cycle day and bevacizumab 15 mg/kg via IV administered on Day 1 of every cycle for every 3 weeks. One cycle consists of 21 days.

Timeline

Start
2021-06-11
Primary completion
2023-10-27
Completion
2023-10-27

Drugs

EvaluationDrugModalityDoseRoute
Subject Bevacizumab Monoclonal antibody 15 mg/kg Intravenous
Subject Olaparib Small molecule 300 mg Oral

Indications