drugset
drugset / Trial / NCT04947267

To Compare the Pulpal Oxygen Saturation Level After Administering Mepivacaine With and Without Vasoconstrictor

NCT04947267 ↗

Phase 2 Completed 60 enrolled Afshan Amjad Ali
RandomizedParallel-groupQuadruple-blindDiagnostic

Summary

As vasoconstrictors adversely affect pulpal hemodynamics, this study compared the pulpal oxygen saturation levels after employing inferior alveolar nerve block with 2% mepivacaine with 1:100,000 epinephrine (2% Scandonest Special) and 3% mepivacaine (3% Scandonest Plain).Two groups were made with 30 patients in each group. 2% mepivacaine with 1:100,000 epinephrine (2% Scandonest Special) was administered to the patients in Group A whereas 3% mepivacaine (3% Scandonest Plain) was administered to the patients in Group B. Rubber dam application, cavity preparation and composite filling was then done on the selected carious mandibular premolar. Pulpal oxygen saturation levels were recorded after administration of local anesthesia with Nellcor-550 pulse oximeter and Nellcor D-YS Multisite reusable sensor.

Timeline

Start
2018-05-30
Primary completion
2019-09-21
Completion
2019-11-19

Drugs

EvaluationDrugModalityDoseRoute
Comparator Epinephrine Other / unclassified — Other
Subject Mepivacaine Other / unclassified 1.8 ml Other
Subject Mepivacaine Other / unclassified 2 % Other
Subject Mepivacaine Other / unclassified 3 % Other

Indications

No indication recorded.