drugset / Trial / NCT04948463
Early Versus Late Stopping of Antibiotics in Children With Cancer and High-risk Febrile Neutropenia
RandomizedParallel-groupOpen-labelTreatment
Summary
This randomised controlled trial will determine the non-inferiority of stopping empiric antibiotics prior to absolute neutrophil count (ANC) recovery (Early Stopping) versus stopping antibiotics upon ANC recovery (Standard of Care/ Late Stopping) , in children with cancer and high-risk febrile neutropenia (FN).
Timeline
- Start
- 2021-11-15
- Primary completion
- 2025-12-17
- Completion
- 2025-12-17
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Amikacin | Small molecule | 18 mg/kg | — |
| Subject | Amikacin | Small molecule | 22.5 mg/kg | — |
| Subject | Cefepime | Small molecule | 50 mg/kg | — |
| Subject | Ceftazidime | Small molecule | 50 mg/kg | — |
| Subject | Ciprofloxacin | Small molecule | 10 mg/kg | — |
| Subject | Piperacillin | Small molecule | 100 mg/kg | — |
| Subject | Tazobactam | Small molecule | 100 mg/kg | — |
| Subject | Vancomycin | Other / unclassified | 15 mg/kg | — |