Influence of Postoperative Cognitive Function in Patients With Sevoflurane Postconditioning on Carotid Intima Stripped

Phase 0 Unknown 140 enrolled Second Affiliated Hospital, School of Medicine, Zhejiang University

RandomizedSingle-groupSingle-blindOther

Summary

Brief summary: In order to get a better clinical plan for brain protection during perioperative anesthesia for high-risk patients - carotid intima stripped. We observing the hemodynamic changes of sevoflurane post-treatment in carotid intima stripped, the comparison of postoperative cognitive function and postoperative radiographic changes.

Timeline

Start: 2021-06-01
Primary completion: 2022-12-31
Completion: 2022-12-31

Outcome

Met primary endpoint

paper A significant between-group difference was therefore evident on postoperative day 1 (MMSE p = 0.002; MoCA p = 0.037) PMID 41438154 ↗

paper Low-dose sevoflurane post-conditioning provides superior short-term preservation of cognitive function compared to standard anesthesia PMID 41438154 ↗

Publications

Wang B, Li S, Wang C, Zhu J, Jin Y, Sun D, Lang J. Effect of sevoflurane post-conditioning on postoperative cognitive function in carotid endarterectomy patients: a randomized, double-blind, controlled trial. Front Med (Lausanne). 2025 Dec 8;12:1716370. doi: 10.3389/fmed.2025.1716370. eCollection 2025.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Sevoflurane	Other / unclassified	1 %	—