drugset / Trial / NCT04962451

Comparison of the Efficacy of Ticagrelor Combined With ASA to ASA Alone in Patients With Stroke

NCT04962451 ↗

Phase 4 Completed 13000 enrolled Peking University Third Hospital AstraZeneca · collab
RandomizedParallel-groupDouble-blindTreatment

Summary

Cerebrovascular disease is the main cause of death and severe long-term disability worldwide. Antiplatelet drugs are the main drugs for ischemic stroke and TIA. Cyclooxygenase inhibitor acetylsalicylic acid (ASA) has always been the most widely studied antiplatelet therapy. The studies of acrates of aliscon body evaluated the efficacy and safety of ticagrelor monotherapy in preventing major vascular events in patients with AIS or TIA. The results showed that the number of patients with endpoint events in ticagrelor group was less than that in ASA group, However, it has not been proved that ticagrelor monotherapy is better than ASA. The purpose of this study is to prove that ticagrelor is better than ASA.

Timeline

Start
2017-09-01
Primary completion
2019-09-30
Completion
2019-10-31

Drugs

EvaluationDrugModalityDoseRoute
Subject Ticagrelor Small molecule 90 mg —
Background Aspirin Small molecule 75 mg —
Background Aspirin Small molecule 100 mg —

Indications