drugset / Trial / NCT04969627

Effects of GLP-1 Analogue Combined With Metformin and Metformin on Gonadal and Metabolic Profiles in Chinese Overweight/Obese PCOS Patients With Hyperandrogenemia.

NCT04969627

Phase 4 Completed 60 enrolled Bing He
RandomizedParallel-groupOpen-labelTreatment

Summary

To study the effects of GLP-1 analogues combined with metformin and metformin on gonadal and metabolic profiles in PCOS patients with BMI ≥ 24 in China. 60 cases of overweight PCOS patients were collected from Shengjing hospital. The intervention period was 3 months after intervention with met or met + GLP-1. To evaluate the improvement of met or met + GLP-1 in the treatment of hyperandremia, glucose metabolism, BMI, waist circumference, menstruation, hairiness and acne in PCOS patients with different BMI.

Timeline

Start
2021-01-04
Primary completion
2022-01-04
Completion
2022-03-29

Drugs

EvaluationDrugModalityDoseRoute
Subject Exenatide Peptide 5 ug
Subject Exenatide Peptide 10 ug
Subject Metformin Small molecule 1500 mg
Subject Metformin Small molecule 2000 mg