drugset / Trial / NCT04969627
Effects of GLP-1 Analogue Combined With Metformin and Metformin on Gonadal and Metabolic Profiles in Chinese Overweight/Obese PCOS Patients With Hyperandrogenemia.
RandomizedParallel-groupOpen-labelTreatment
Summary
To study the effects of GLP-1 analogues combined with metformin and metformin on gonadal and metabolic profiles in PCOS patients with BMI ≥ 24 in China. 60 cases of overweight PCOS patients were collected from Shengjing hospital. The intervention period was 3 months after intervention with met or met + GLP-1. To evaluate the improvement of met or met + GLP-1 in the treatment of hyperandremia, glucose metabolism, BMI, waist circumference, menstruation, hairiness and acne in PCOS patients with different BMI.
Timeline
- Start
- 2021-01-04
- Primary completion
- 2022-01-04
- Completion
- 2022-03-29
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Exenatide | Peptide | 5 ug | — |
| Subject | Exenatide | Peptide | 10 ug | — |
| Subject | Metformin | Small molecule | 1500 mg | — |
| Subject | Metformin | Small molecule | 2000 mg | — |