drugset / Trial / NCT04984226
Sodium Bicarbonate and Mitochondrial Energetics in Persons With CKD
Phase 2
Recruiting
80 enrolled
University of California, Davis
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · collabVanderbilt University Medical Center · collab
RandomizedCrossoverQuadruple-blindPrevention
Summary
Skeletal muscle metabolic health is critical for mobility and an underrecognized target of metabolic acidosis in chronic kidney disease. Impaired muscle mitochondrial metabolism underlies poor physical endurance increasing the risk of mobility disability. The proposed project will use precise in vivo tools to study the pathophysiology of poor physical endurance in a clinical trial treating metabolic acidosis among persons living with chronic kidney disease.
Timeline
- Start
- 2023-09-08
- Primary completion
- 2026-12-31
- Completion
- 2026-12-31
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | sodium bicarbonate | Diagnostic / imaging agent | 0.8 meq | — |