drugset / Trial / NCT04994119

Effect of BIA 5-1058 400 mg on Warfarin Pharmacokinetics

NCT04994119

Phase 1 Completed 26 enrolled Bial - Portela C S.A.
RandomizedSequentialOpen-labelTreatment

Summary

The purpose of this study is: * To investigate CYP2C9 inhibition by BIA 5-1058 through the assessment of its effect on the Pharmacokinetic (PK) of S-warfarin, a substrate of CYP2C9. * To assess the effect of warfarin on the PK of BIA 5-1058.

Timeline

Start
2018-02-23
Primary completion
2018-05-23
Completion
2018-05-23

Drugs

EvaluationDrugModalityDoseRoute
Subject Warfarin Small molecule 25 mg Oral
Subject zamicastat Small molecule 400 mg Oral