drugset / Trial / NCT04994119
Effect of BIA 5-1058 400 mg on Warfarin Pharmacokinetics
RandomizedSequentialOpen-labelTreatment
Summary
The purpose of this study is: * To investigate CYP2C9 inhibition by BIA 5-1058 through the assessment of its effect on the Pharmacokinetic (PK) of S-warfarin, a substrate of CYP2C9. * To assess the effect of warfarin on the PK of BIA 5-1058.
Timeline
- Start
- 2018-02-23
- Primary completion
- 2018-05-23
- Completion
- 2018-05-23
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Warfarin | Small molecule | 25 mg | Oral |
| Subject | zamicastat | Small molecule | 400 mg | Oral |