A Study of Danavorexton in Anesthetized Adults

Phase 1 Completed 28 enrolled Takeda

RandomizedSequentialDouble-blindOther

Summary

The aims of the study are: * to assess the safety profile of danavorexton when it is administered with anesthetics. * to learn what effect danavorexton has on anesthetized adults. On Day 1, participants will receive a single intravenous (IV) infusion of danavorexton or a placebo after participants have been anesthetized for about 40 minutes. Clinic doctors will arrange a follow-up visit by phone or video on Day 7.

Timeline

Start: 2021-09-28
Primary completion: 2022-03-08
Completion: 2022-03-08

Publications

Suzuki M, Shiraishi E, Cronican J, Kimura H. Effects of the orexin receptor 2 agonist danavorexton on emergence from general anaesthesia and opioid-induced sedation, respiratory depression, and analgesia in rats and monkeys. Br J Anaesth. 2024 Mar;132(3):541-552. doi: 10.1016/j.bja.2023.12.032. Epub 2024 Feb 1.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Danavorexton	Small molecule	—	Intravenous
Background	Propofol	Small molecule	—	Intravenous
Background	Sevoflurane	Other / unclassified	—	Inhaled

Indications

No indication recorded.