Effects of Low Dose Aspirin in Bipolar Disorder (The A-Bipolar RCT)

Summary

Despite currently available treatment, a large proportion of patients with bipolar disorder (BD) suffer from affective symptoms, impaired psychosocial and cognitive function. Inflammation seems to be involved in the pathogenesis of BD and preliminary data suggest that low-dose Aspirin may have beneficial effects. The objective of this RCT is to investigate whether add on of low dose aspirin versus placebo add on to standard drug treatment improves mood stabilisation and other critical patient outcomes in patients with BD and whether its principal effects are antimanic, antidepressant or prophylactic against relapse. randomized double-blinded placebo-controlled trial will investigate whether augmentation with low dose Aspirin to standard drug treatment improve mood stabilization.

Timeline

Start

2022-01-20

Primary completion

2024-11-18

Completion

2024-11-18

Publications

• Bruun CF, Krogh HB, Zarp J, Stokholm JR, Forman JL, Miskowiak KW, Giraldi A, Vinberg M, Faurholt-Jepsen M, Kessing LV. No Effect of Low-Dose Aspirin Versus Placebo as Add-On Treatment in Bipolar Disorder-Results From a Randomised Controlled Trial (the A-Bipolar RCT). Acta Psychiatr Scand. 2026 Mar;153(3):214-224. doi: 10.1111/acps.70055. Epub 2025 Nov 30.
• Bruun CF, Zarp J, Lyng Forman J, Coello K, Miskowiak KW, Vinberg M, Faurholt-Jepsen M, Kessing LV. Effects of low-dose aspirin in bipolar disorder: study protocol for a randomised controlled trial (the A-Bipolar RCT). BMJ Open. 2024 Nov 18;14(11):e084105. doi: 10.1136/bmjopen-2024-084105.

Drugs

Indications