drugset / Trial / NCT05039580
Programmed Cell Death Protein-1 (PD-1) Monoclonal Antibody for EBV-HLH and CAEBV as First-line Therapy
NaSingle-groupOpen-labelTreatment
Summary
EBV-HLH and CAEBV are both caused by EBV infection, part of them can rapidly lead to a syndrome of severe, life-threatening hyper-inflammation, with poor prognosis. Currently, the most effective treatment remains unknown. This study is trying to evaluate the efficacy and safety of PD-1 monoclonal antibody as a first-line therapy for EBV-HLH and CAEBV.
Timeline
- Start
- 2021-05-15
- Primary completion
- 2023-04-30
- Completion
- 2023-04-30
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Background | Dexamethasone | Small molecule | — | Intrathecal |
| Background | Ruxolitinib | Small molecule | — | — |