drugset / Trial / NCT05039580

Programmed Cell Death Protein-1 (PD-1) Monoclonal Antibody for EBV-HLH and CAEBV as First-line Therapy

NCT05039580

NaSingle-groupOpen-labelTreatment

Summary

EBV-HLH and CAEBV are both caused by EBV infection, part of them can rapidly lead to a syndrome of severe, life-threatening hyper-inflammation, with poor prognosis. Currently, the most effective treatment remains unknown. This study is trying to evaluate the efficacy and safety of PD-1 monoclonal antibody as a first-line therapy for EBV-HLH and CAEBV.

Timeline

Start
2021-05-15
Primary completion
2023-04-30
Completion
2023-04-30

Drugs

EvaluationDrugModalityDoseRoute
Background Dexamethasone Small molecule Intrathecal
Background Ruxolitinib Small molecule