drugset / Trial / NCT05045170

Sedation and Memory Consolidation

NCT05045170 ↗

RandomizedParallel-groupSingle-blindBasic science

Summary

The study of plasticity processes, in particular, memory, is one of the fundamental directions in anesthesiology. To date, there are different views on the impact of sedation and anesthesia on memory. Memory consolidation is one of the most crucial processes that the anesthesiologist is interested in. Memory consolidation is the mechanism of transferring short-term memory to long-term memory. The investigators suppose that propofol or dexmedetomidine sedation disrupts memory consolidation. In addition, the investigators inquired about the impact of sedation on 'working memory'. Therefore, a better understanding of the influence of anesthesia and sedation on basic memory processes will allow the anesthesiologist to balance the choice of the drug and ensure the patient's safety in the intraoperative period.

Timeline

Start
2021-05-11
Primary completion
2022-01-13
Completion
2022-01-13

Drugs

EvaluationDrugModalityDoseRoute
Subject Dexmedetomidine Other / unclassified 0.6 ug/kg Intravenous
Subject Dexmedetomidine Other / unclassified 0.7 ug/kg Intravenous
Subject Propofol Small molecule 2.5 ug/ml Intravenous

Indications