drugset / Trial / NCT05051189
Effect of Opioids on Central Control of Ventilation in Children With Obstructive Sleep Apnea
Phase 0
Completed
90 enrolled
Baylor College of Medicine
Children's Hospital of Philadelphia · collabUniversity of Houston · collabWake Forest University · collab
RandomizedParallel-groupSingle-blindDiagnostic
Summary
Children OSA exhibit varying responses to opioids. It is unknown if the degree of intermittent hypoxemia results in different opioid sensitivity
Timeline
- Start
- 2021-12-01
- Primary completion
- 2024-11-01
- Completion
- 2024-11-01
Publications
- Results Adler AC, Chandrakantan A, Nathanson BH, von Ungern-Sternberg BS. An assessment of opioids on respiratory depression in children with and without obstructive sleep apnea. Paediatr Anaesth. 2021 Sep;31(9):977-984. doi: 10.1111/pan.14228. Epub 2021 Jun 16.
- Adler AC, Lin EE, Messner AH, Rosenberg TL, Pecorella S, Keleghan A, Faircloth S, Templeton TW, Harris L, Khan SA, Pednekar GS, Nguyen DT, Chandrakantan A, von Ungern-Sternberg BS. Association of preoperative nocturnal hypoxaemia nadir and fentanyl ventilatory sensitivity in children with obstructive sleep apnoea undergoing general anaesthesia: a multicentre clinical cohort study. Br J Anaesth. 2025 Nov;135(5):1518-1527. doi: 10.1016/j.bja.2025.07.059. Epub 2025 Sep 5.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Fentanyl | Other / unclassified | 1 ug/kg | Intravenous |
| Comparator | Fentanyl | Other / unclassified | 1.5 ug/kg | Intravenous |