Implication of Metformin Plus Aromatase Inhibitor in Obese Postmenopausal Breast Cancer Women

Summary

Metformin is an anti-diabetic oral hypoglycemic agent that considered the gold standard therapy for the treatment of type 2 diabetes. Retrospective analyses show that metformin can offer therapeutic benefits to patients with several forms of cancer. It also has positive weight reducing effect on non-diabetic patient by improving insulin sensitivity (although the exact underlying pathomechanisms remain to be elucidated).

Timeline

Start

2014-02

Primary completion

2015-06

Completion

2015-06

Publications

• El-Attar AA, Ibrahim OM, Alhassanin SA, Essa ES, Mostafa TM. Effect of metformin as an adjuvant therapy to letrozole on estradiol and other biomarkers involved in the pathogenesis of breast cancer in overweight and obese postmenopausal women: a pilot study. Eur J Clin Pharmacol. 2023 Feb;79(2):299-309. doi: 10.1007/s00228-022-03444-6. Epub 2022 Dec 23.

Drugs

Indications