drugset / Trial / NCT05064904

Multidiscipline Care for Acute Kidney Disease (AKD)

NCT05064904

RandomizedParallel-groupSingle-blindPrevention

Summary

The Taiwan Consortium of Acute Kidney Injury and Renal Diseases (TCTC) is leading a clinical trial group in Asia-Pacific to reduce the morbidity and mortality associated with acute kidney injury (AKI). The trial is a double two-by-two factorial design that will collect demographic and clinical information of AKI stage 2, 3, or weaning from dialysis-requiring AKI patients (AKI-D) to explore the epidemiology, risk factors and prognosis of AKI in Taiwan. Patients will be randomized either to add Angiotensin-Converting Enzyme Inhibitors (ACE-I)/Angiotensin II Receptor Blocker (ARB) to slow kidney function progression, or to receive multidisciplinary care. Patients will be followed up for a minimum of 6 months to evaluate kidney function, the predictability of developing chronic kidney disease, end stage renal disease, major cardiovascular events, and mortality.

Timeline

Start
2019-02-15
Primary completion
2024-01-06
Completion
2024-02-15

Drugs

EvaluationDrugModalityDoseRoute
Comparator Captopril Small molecule 25 mg
Comparator Losartan Other / unclassified 50 mg

Indications