Vaped Marijuana to Attenuate Naloxone-Precipitated Withdrawal

Summary

The goal of the proposed, proof-of-concept study is to test the combined effects of vaporized marijuana \[Delta-9-tetrahydracannabinol (THC)\] with NLX as a proof of concept towards the possible development of a combined overdose reversal agent with improved tolerability.

Timeline

Start

2021-11-01

Primary completion

2024-10-15

Completion

2024-10-29

Publications

• Jones JD, Martinez S, Arout C, Haney M, Castillo F, Manubay J, Perez F, Luba RR, Comer SD. The effects of vaped cannabis on the severity of naloxone-precipitated opioid withdrawal. Exp Clin Psychopharmacol. 2026 Jun;34(3):318-323. doi: 10.1037/pha0000796. Epub 2025 Aug 21.

Drugs

Indications