Pre-emptive Intravenous Morphine for Acute Post-craniotomy Pain.

Summary

We propose a double-blind randomized controlled trial to evaluate the effect of intravenously administered morphine at surgery conclusion on acute postoperative pain in patients recovering from craniotomy surgery. Participating adults having craniotomy surgery will be randomized in a 1:1 ratio to intraoperative intravenous administration of 0.08 mg/kg morphine at dura closure, or a matching placebo.

Timeline

Start

2022-02-16

Primary completion

2025-05-01

Completion

2025-05-01

Drugs

Indications