drugset / Trial / NCT05143125

Treatment of Malignant Tumors With NK Cell

NCT05143125

Phase 1/2 Unknown 60 enrolled Shenzhen University General Hospital
NaSingle-groupOpen-labelPrevention

Summary

Natural killer cells (NK cells) are derived from bone marrow lymphoid stem cells, which are a type of lymphocytes that can non-specifically kill tumor cells and virus-infected cells without pre-sensitization. NK cells can not only directly kill malignant diseased cells, but also participate in the regulation of immune cell response and play a role in a variety of tumor immunotherapy strategies. The 2-year survival rate of NK cells combined with stem cell therapy for patients with hematological malignancies reached 36%, which is significantly higher than the 2-year survival rate (about 15%) of stem cell therapy alone, which can extend the disease-free survival period of leukemia patients by an average of 1.5 years. Relapsed and refractory leukemia can achieve a complete remission rate of up to 40%.

Timeline

Start
2021-02-05
Primary completion
2024-02
Completion
2024-02

Drugs

EvaluationDrugModalityDoseRoute
Subject Decitabine Small molecule
Subject TROCULEUCEL Cell therapy Other

Indications