drugset / Trial / NCT05154396

Neratinib Dose Escalation Regimen for HER2 Positive Early Breast Cancer

NCT05154396

Phase 2 Unknown 60 enrolled Chinese Academy of Medical Sciences
RandomizedParallel-groupOpen-labelTreatment

Summary

This is a prospective study on the prevention of Neratinib-related diarrhea in a Chinese population, exploring the best options for reducing the incidence of neratinib-related diarrhea through either pharmacologic intervention (prophylactic antidiarrheal therapy) or non-pharmacologic intervention (dose escalation program).

Timeline

Start
2022-01-01
Primary completion
2023-12-31
Completion
2024-12-31

Drugs

EvaluationDrugModalityDoseRoute
Subject Loperamide Small molecule 4 mg
Subject Neratinib Small molecule 240 mg