drugset / Trial / NCT05154396
Neratinib Dose Escalation Regimen for HER2 Positive Early Breast Cancer
RandomizedParallel-groupOpen-labelTreatment
Summary
This is a prospective study on the prevention of Neratinib-related diarrhea in a Chinese population, exploring the best options for reducing the incidence of neratinib-related diarrhea through either pharmacologic intervention (prophylactic antidiarrheal therapy) or non-pharmacologic intervention (dose escalation program).
Timeline
- Start
- 2022-01-01
- Primary completion
- 2023-12-31
- Completion
- 2024-12-31
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Loperamide | Small molecule | 4 mg | — |
| Subject | Neratinib | Small molecule | 240 mg | — |