drugset / Trial / NCT05154682

Pain Management After Surgery

NCT05154682

Phase 3 Unknown 200 enrolled Rothman Institute Orthopaedics
RandomizedParallel-groupOpen-labelTreatment

Summary

Following outpatient orthopaedic surgery, adequate pain control is imperative both for patient satisfaction and for improved recovery and rehabilitation. Opioids are frequently utilized for postoperative pain control, however they can be addictive and are known to have many deleterious effects. Recent studies have demonstrated the effectiveness of a wide variety of multi-modal postoperative pain regimens in providing adequate pain control while also decreasing opioid usage. However, the most effective multi-modal pain regimen for postoperative pain control remains unclear. This prospective, randomized study intends to investigate the efficacy of a multi-modal postoperative pain regimen compared to a traditional opioid-only pain regimen following elective outpatient orthopaedic surgery of the hand, wrist, foot, or ankle.

Timeline

Start
2021-11-30
Primary completion
2022-11-30
Completion
2022-11-30

Drugs

EvaluationDrugModalityDoseRoute
Comparator Acetaminophen Small molecule 500 mg
Comparator Naproxen Small molecule 500 mg
Comparator Oxycodone Other / unclassified 5 mg Oral

Indications