Dexketoprofen Dosage According to Chronotherapy

Summary

Lower third molar extraction is one of the most common treatments in oral surgery practice. It is a treatment with inherent complications such as postoperative pain, swelling or trismus. In order to minimize disconfort after extraction, analgesic and anti-inflammatory medication is prescribed. Recently, it is seen that circadian rhythm may play an important role on drugs metabolism, modulating its effect depending on the moment of administration. The aim of the study is to analyze if dosage modification of a Non Steroideal Anti-Inflammatory (dexketoprofen) affects on postoperative pain, swelling and open mouth limitation according the circadian clock

Timeline

Start

2024-11-01

Primary completion

2024-11-01

Completion

2024-11-01

Publications

• Perez-Gonzalez F, Abusamak M, Ruiz LV, Saez-Alcaide LM, Al-Waeli H, Tamimi F, Garcia-Denche JT. Dexketoprofen Time-Dependent Administration After Third Molar Extraction: A Pilot Randomized Cross-Over Controlled Trial. Clin Exp Dent Res. 2026 Feb;12(1):e70163. doi: 10.1002/cre2.70163.

Drugs

Indications