drugset
drugset / Trial / NCT05177588

Efficacy of Metformin as add-on Therapy in Non-Diabetic Heart Failure Patients

NCT05177588 ↗

Phase 4 Completed 70 enrolled Cairo University
RandomizedParallel-groupSingle-blindTreatment

Summary

There is an increasing interest in the use of metformin in CV diseases and there is an increasing interest in studying its potential new roles in heart failure patients. There were some concerns related to the safety of metformin in such diabetic patients due to the risk of lactic acidosis. However, recent studies showed that metformin was safe or even beneficial in HF patients. We hypothesized that metformin might improve morbidity, mortality, cardiac function, and HR-QoL in non-diabetic patients with HFrEF.

Timeline

Start
2021-07-21
Primary completion
2023-03-30
Completion
2023-04-30

Publications

Drugs

EvaluationDrugModalityDoseRoute
Subject Metformin Small molecule 2000 mg —

Indications

heart failure