Early Antiplatelet for Minor Stroke Following Thrombolysis (EAST)

Summary

The current guideline recommends to give antithrombotic treatment 24 hours after intravenous thrombolysis in acute ischemic stroke. However, early neurological deterioration will occur in some patients due to no antithrombotic treatment, which is closely associated with poor outcome. The current trial aims to investigate the effectiveness and safety of early antithrombotic treatment after intravenous thrombolysis in minor stroke.

Timeline

Start

2022-07-08

Primary completion

2024-10-25

Completion

2024-10-25

Publications

• Cui Y, Liu JL, Jiang CH, Hou XW, Chen HS. Diabetes Mellitus and Early Antiplatelet Treatment for Minor Stroke Following Intravenous Thrombolysis: Prespecified Secondary Analysis of the EAST Trial. Diabetes Obes Metab. 2026 Jul;28(7):5604-5613. doi: 10.1111/dom.70745. Epub 2026 Apr 7.

Drugs

Indications