Εffectiveness of Intrauterine Antibiotic Administration for Treatment of Chronic Endometritis

NCT05205993 ↗

Phase 2 Unknown 90 enrolled Genesis Athens Clinic National and Kapodistrian University of Athens · collab

Non-randomizedParallel-groupOpen-labelTreatment

Summary

Chronic Endometritis (CE) is related to infertility and entails a challenging management. This study investigates the treatment of off-label intrauterine antibiotic infusion either separately or combined with oral antibiotic administration, and it assesses respective performance against the gold standard treatment of oral antibiotic adminstration. Data sourced herein reports on treatment efficiency, defined as a negative diagnosis for chronic endometritis.

Timeline

Start: 2021-01-19
Primary completion: 2024-01-30
Completion: 2024-04-30

Publications

Background Pantos K, Simopoulou M, Maziotis E, Rapani A, Grigoriadis S, Tsioulou P, Giannelou P, Nitsos N, Tzonis P, Koutsilieris M, Sfakianoudis K. Introducing intrauterine antibiotic infusion as a novel approach in effectively treating chronic endometritis and restoring reproductive dynamics: a randomized pilot study. Sci Rep. 2021 Aug 2;11(1):15581. doi: 10.1038/s41598-021-95072-w.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Ciprofloxacin	Small molecule	3 ml	Other
Subject	Doxycycline	Small molecule	100 mg	Oral
Subject	Metronidazole	Small molecule	500 mg	Oral

Εffectiveness of Intrauterine Antibiotic Administration for Treatment of Chronic Endometritis

Summary

Timeline

Publications

Drugs

Indications