drugset / Trial / NCT05206448
Randomized Controlled Trial of Combined Letrozole and Clomid (CLC II) Versus Letrozole Alone for Women With Anovulation
Phase 4
Active not recruiting
190 enrolled
Rachel Mejia
American Society for Reproductive Medicine · collabSociety for Reproductive Investigation · collabUniversity of Wisconsin, Madison · collab
RandomizedParallel-groupOpen-labelTreatment
Summary
This study evaluates the addition of clomiphene citrate (CC) to letrozole for the treatment of infertility in women with polycystic ovary syndrome across a course of two treatment cycles with stair step dosing of letrozole similar to standard of care. Half of the participants will receive letrozole and CC in combination, while the other half will receive letrozole alone.
Timeline
- Start
- 2020-10-26
- Primary completion
- 2024-04-12
- Completion
- 2025-12
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Clomiphene | Other / unclassified | 50 mg | Oral |
| Subject | Letrozole | Other / unclassified | 2.5 mg | Oral |
| Subject | Letrozole | Other / unclassified | 5 mg | Oral |
| Subject | Letrozole | Other / unclassified | 7.5 mg | Oral |