drugset / Trial / NCT05212597
Open Label RCT for Chronic Severe AR : Entresto vs. CCB/ARB
RandomizedParallel-groupOpen-labelTreatment
Summary
The purpose of this study is to assess the efficacy of sacubitril-valsartan compared to the combination of ARB/CCB on left ventricular remodeling in patients with chronic aortic valve regurgitation.
Timeline
- Start
- 2022-01-12
- Primary completion
- 2023-12
- Completion
- 2024-12
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Amlodipine | Other / unclassified | 5 mg | — |
| Comparator | Losartan | Other / unclassified | 100 mg | — |
| Comparator | Sacubitril-Valsartan | Unknown | 100 mg | — |