drugset / Trial / NCT05215834
The Comparison of Remimazolam With Propofol in Core Body Temperature
RandomizedParallel-groupOpen-labelScreening
Summary
1. Core body temperature is normally tightly regulated to within a few tenths of a degree. The major thermoregulatory defences in humans are sweating, arteriovenous shunt vasoconstriction, and shivering. 2. Inadvertent hypothermia often complicates prolonged surgery. In patients becoming sufficiently hypothermic, reemergence of thermoregulatory vasoconstriction usually prevents further core hypothermia. 3. The extent to which anesthetics reduce the vasoconstriction threshold depends on the type of drug and its concentration.
Timeline
- Start
- 2021-03-01
- Primary completion
- 2021-06-30
- Completion
- 2021-11-30
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Background | Remifentanil | Small molecule | 3 ng/ml | Intravenous |
Indications
No indication recorded.