drugset / Trial / NCT05215873
Induction of Labor in Pregnant Women With Prelabor Rupture of Membranes - Oxytocin or Misoprostol
RandomizedParallel-groupOpen-labelTreatment
Summary
The aim of study is to compare the efficacy and safety of oral misoprostol versus oxytocin in induction of labor in pregnant women with prelabor rupture of membranes at term.
Timeline
- Start
- 2021-02-01
- Primary completion
- 2022-01-15
- Completion
- 2022-05-16
Publications
- Background Alfirevic Z, Aflaifel N, Weeks A. Oral misoprostol for induction of labour. Cochrane Database Syst Rev. 2014 Jun 13;2014(6):CD001338. doi: 10.1002/14651858.CD001338.pub3.
- Background Zeteroglu S, Engin-Ustun Y, Ustun Y, Guvercinci M, Sahin G, Kamaci M. A prospective randomized study comparing misoprostol and oxytocin for premature rupture of membranes at term. J Matern Fetal Neonatal Med. 2006 May;19(5):283-7. doi: 10.1080/14767050600589807.
- Ahmed RHM, Sweed MSE, El-Bishry GA, Hassan RK. Oxytocin Versus Oral Misoprostol for Induction of Labor in Pregnant Women with Term Prelabor Rupture of Membranes: a Randomized Clinical Trial. Reprod Sci. 2023 Dec;30(12):3507-3514. doi: 10.1007/s43032-023-01290-0. Epub 2023 Jul 13.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Misoprostol | Other / unclassified | 25 ug | Oral |
| Comparator | Oxytocin | Peptide | 3 iu | — |