Efficacy of Lithium Against Chemotherapy Induced Neutropenia in Breast Cancer Patients

Summary

Using Lithium Carbonate to decrease incidence of neutropenia caused by using chemotherapy regimen in breast cancer patients.

Timeline

Start

2020-08-01

Primary completion

2022-04-01

Completion

2022-06-01

Publications

• Background Bodey GP, Buckley M, Sathe YS, Freireich EJ. Quantitative relationships between circulating leukocytes and infection in patients with acute leukemia. Ann Intern Med. 1966 Feb;64(2):328-40. doi: 10.7326/0003-4819-64-2-328. No abstract available.
• Background el-Mallakh RS. Lithium. Conn Med. 1990 Mar;54(3):115-26.
• Background Slater V, Milanes F, Talcott V, Okafor KC. Influence of age on lithium therapy. South Med J. 1984 Feb;77(2):153-4, 158. doi: 10.1097/00007611-198402000-00003.
• Background Yassa R. Leukocytosis during long-term lithium treatment. N Y State J Med. 1981 Sep;81(10):1479-80. No abstract available.
• Background Ballin A, Lehman D, Sirota P, Litvinjuk U, Meytes D. Increased number of peripheral blood CD34+ cells in lithium-treated patients. Br J Haematol. 1998 Jan;100(1):219-21. doi: 10.1046/j.1365-2141.1998.00537.x.
• Background RADOMSKI JL, FUYAT HN, NELSON AA, SMITH PK. The toxic effects, excretion and distribution of lithium chloride. J Pharmacol Exp Ther. 1950 Dec;100(4:1):429-44. No abstract available.
• Background Petrini M, Vaglini F, Carulli G, Azzara A, Ambrogi F, Bertelli A. Effects of lithium and rubidium on the differentiation of mononuclear cells. Int J Tissue React. 1986;8(5):391-2.
• Background Tisman G, Herbert V, Rosenblatt S. Evidence that lithium induces human granulocyte proliferation: elevated serum vitamin B 12 binding capacity in vivo and granulocyte colony proliferation in vitro. Br J Haematol. 1973 Jun;24(6):767-71. doi: 10.1111/j.1365-2141.1973.tb01704.x. No abstract available.
• Background Harker WG, Rothstein G, Clarkson D, Athens JW, Macfarlane JL. Enhancement of colony-stimulating activity production by lithium. Blood. 1977 Feb;49(2):263-7.
• Background Levitt LJ, Quesenberry PJ. The effect of lithium on murine hematopoiesis in a liquid culture system. N Engl J Med. 1980 Mar 27;302(13):713-9. doi: 10.1056/NEJM198003273021303.
• Background Stein RS, Hanson G, Koethe S, Hansen R. Lithium-induced granulocytosis. Ann Intern Med. 1978 Jun;88(6):809-10. doi: 10.7326/0003-4819-88-6-809_2. No abstract available.
• Background Kast RE. How lithium treatment generates neutrophilia by enhancing phosphorylation of GSK-3, increasing HIF-1 levels and how this path is important during engraftment. Bone Marrow Transplant. 2008 Jan;41(1):23-6. doi: 10.1038/sj.bmt.1705872. Epub 2007 Oct 1.
• Background Li H, Huang K, Liu X, Liu J, Lu X, Tao K, Wang G, Wang J. Lithium chloride suppresses colorectal cancer cell survival and proliferation through ROS/GSK-3beta/NF-kappaB signaling pathway. Oxid Med Cell Longev. 2014;2014:241864. doi: 10.1155/2014/241864. Epub 2014 Jun 5.
• Background de Araujo WM, Robbs BK, Bastos LG, de Souza WF, Vidal FC, Viola JP, Morgado-Diaz JA. PTEN Overexpression Cooperates With Lithium to Reduce the Malignancy and to Increase Cell Death by Apoptosis via PI3K/Akt Suppression in Colorectal Cancer Cells. J Cell Biochem. 2016 Feb;117(2):458-69. doi: 10.1002/jcb.25294.
• Background Maeng YS, Lee R, Lee B, Choi SI, Kim EK. Lithium inhibits tumor lymphangiogenesis and metastasis through the inhibition of TGFBIp expression in cancer cells. Sci Rep. 2016 Feb 9;6:20739. doi: 10.1038/srep20739.
• Background Zhong Z, Sanchez-Lopez E, Karin M. Autophagy, Inflammation, and Immunity: A Troika Governing Cancer and Its Treatment. Cell. 2016 Jul 14;166(2):288-298. doi: 10.1016/j.cell.2016.05.051.
• Background Sarkar S, Floto RA, Berger Z, Imarisio S, Cordenier A, Pasco M, Cook LJ, Rubinsztein DC. Lithium induces autophagy by inhibiting inositol monophosphatase. J Cell Biol. 2005 Sep 26;170(7):1101-11. doi: 10.1083/jcb.200504035.
• Background Lyman GH, Williams CC, Preston D, Goldman A, Dinwoodie WR, Saba H, Hartmann R, Jensen R, Shukovsky L. Lithium carbonate in patients with small cell lung cancer receiving combination chemotherapy. Am J Med. 1981 Jun;70(6):1222-9. doi: 10.1016/0002-9343(81)90831-7.

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