Drugs / Lithium Carbonate
last change Aug 2026 re-read 9 days ago

Lithium Carbonate

also known as lithium
Developed for
bipolar disorder · spinal cord injury · acute myeloid leukemia with 11q23 abnormalities · acute myeloid leukemia with t(8;21)(q22;q22) translocation · acute myeloid leukemia, t(16;16)(p13.1;q22) · amyotrophic lateral sclerosis · bipolar I disorder · brain cancer
+38 more · depressive disorder · acute erythroid leukemia · acute megakaryoblastic leukemia in adult · acute myeloblastic leukemia with maturation · acute myeloblastic leukemia without maturation · acute myeloid leukemia, del(5q31-q32) · acute myeloid leukemia, inv(16)(p13.1;q22) · acute myelomonocytic leukemia M4 · adult acute monocytic leukemia · Alzheimer disease · autism spectrum disorder · bipolar II disorder · cardiac valvular defect · carotid stenosis · classic familial adenomatous polyposis · cognitive impairment with or without cerebellar ataxia · Cornelia de Lange syndrome · differentiated thyroid carcinoma · frontotemporal dementia · ischemic stroke · Machado-Joseph disease · major depressive disorder · manic bipolar affective disorder · multiple sclerosis · multiple system atrophy · neuralgia · neuropathy, painful · neutropenia · Niemann-Pick disease, type C1 · osteosarcoma · post-traumatic stress disorder · prostate cancer · spinocerebellar ataxia type 1 · spinocerebellar ataxia type 2 · sporadic amyotrophic lateral sclerosis · borderline personality disorder · dysthymic disorder · psychotic disorder
Investigated by
China Spinal Cord Injury Network · National Institute of Mental Health (NIMH) · National Cancer Institute (NCI) · Alzamend Neuro, Inc. · China Medical University, China · China Rehabilitation Research Center
+68 more · Federico II University · Massachusetts General Hospital · Sunnybrook Health Sciences Centre · Academic Medical Center - University of Amsterdam · Al-Azhar University · Alan Davidson Foundation · Alzheimer's Drug Discovery Foundation · Assistance Publique - Hôpitaux de Paris · Atlantic Health System · Buddhist Tzu Chi General Hospital · Canadian Institutes of Health Research (CIHR) · Centre Hospitalier Universitaire Dijon · Chengdu PLA General Hospital · Children's Hospital of Chongqing Medical University · Columbia University · Demikhov Municipal Clinical Hospital 68 · El Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez · Eli Lilly and Company · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) · Federal University of Rio Grande do Sul · FightMND · First Affiliated Hospital of Chongqing Medical University · Forbes Norris MDA/ALS Research Center · Fred Hutchinson Cancer Center · Genentech, Inc. · Guangdong Provincial Hospital of Traditional Chinese Medicine · Hospital de Clinicas de Porto Alegre · JDS Pharmaceuticals · Johnson & Johnson Pharmaceutical Research & Development, L.L.C. · Lindner Center of HOPE · Luzon Foundation · MNDA · Melbourne Health · Merck Sharp & Dohme LLC · Muscular Dystrophy Association · My name'5 Doddie Foundation · NYU Langone Health · Nanfang Hospital, Southern Medical University · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · National Institute of Neurological Disorders and Stroke (NINDS) · Negovsky Reanimatology Research Institute · Paolo Caimi, MD · Qilu Hospital of Shandong University · Research Foundation Flanders · Second Affiliated Hospital of Xi'an Jiaotong University · Second Xiangya Hospital of Central South University · Shanghai 6th People's Hospital · Shanghai Mental Health Center · Shenzhen Second People's Hospital · Stanford University · StemCyte, Inc. · Stichting ALS Nederland · Sun Yat-sen University · TRICALS Foundation · The Second Affiliated Hospital of Chongqing Medical University · The University of Hong Kong · Thierry Latran Foundation · Ulla-Carin Lindquist Foundation · University of California, Los Angeles · University of Kansas Medical Center · University of Milan · University of Pittsburgh · University of Sao Paulo · VA Eastern Colorado Health Care System · VA Office of Research and Development · Vanderbilt-Ingram Cancer Center · Washington University School of Medicine · Xinhua Hospital, Shanghai Jiao Tong University School of Medicine

Regulatory milestones approvals, filings & regulatory actions · 1 recorded

MilestoneJurisdictionBrandIndicationDateSentence it was read from
Approved US (FDA) LITHONATE — 1970-04-06 fda.gov ↗

Trials 48

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 01 trial
Phase 0 NCT03201627 Jul 2017 → Sep 2020 Niemann-Pick disease, type C1 Xinhua Hospital, Shanghai Jiao Tong University School of Medicine Unknown No outcome recorded
Phase 19 trials
Phase 1 NCT06921590 May → Dec 2025 overdue — Alzamend Neuro, Inc. Active not recruiting No outcome recorded
Phase 1 NCT06719544 Jan 2025 — Merck Sharp & Dohme LLC Completed No outcome recorded
Phase 1 NCT02198859 Apr 2014 → Aug 2016 prostate cancer University of Kansas Medical Center Completed No outcome recorded
Phase 1 NCT01820624 Apr 2013 → Oct 2015 acute erythroid leukemia, acute megakaryoblastic leukemia in adult, acute myeloblastic leukemia with maturation, acute myeloblastic leukemia without maturation +7 Paolo Caimi, MD Completed No outcome recorded
Phase 1 NCT01754883 Jan 2011 → Jan 2014 post-traumatic stress disorder, traumatic brain injury VA Eastern Colorado Health Care System Withdrawn No outcome recorded
Phase 1 NCT00683943 May 2008 → Feb 2010 spinocerebellar ataxia type 1 National Institute of Neurological Disorders and Stroke (NINDS) Completed No outcome recorded
Phase 1 NCT00431171 Sep 2007 → Jan 2010 spinal cord injury The University of Hong Kong Completed No outcome recorded
Phase 1 NCT00469937 Feb 2006 → Mar 2009 brain cancer, cognitive disorder, poisoning Vanderbilt-Ingram Cancer Center Terminated No outcome recorded Stop: Enrollment
Phase 1 NCT00986128 Mar 2001 → Oct 2002 bipolar disorder Johnson & Johnson Pharmaceutical Research & Development, L.L.C. Completed No outcome recorded
Phase 1/25 trials · 1 missed
Phase 1/2 NCT07540338 Apr → Dec 2026 expected bipolar I disorder Alzamend Neuro, Inc. Recruiting No outcome recorded
Phase 1/2 NCT06776848 Sep 2025 → Sep 2027 expected — Centre Hospitalier Universitaire Dijon Recruiting No outcome recorded
Phase 1/2 NCT05814640 Feb 2023 → Dec 2026 expected major depressive disorder, splenic sequestration First Affiliated Hospital of Chongqing Medical University Recruiting No outcome recorded
Phase 1/2 NCT01471613 Sep 2011 → Dec 2013 spinal cord injury China Spinal Cord Injury Network Completed No outcome recorded
Phase 1/2 NCT01259388 May 2011 → Aug 2015 multiple sclerosis VA Office of Research and Development Completed Missed primary
Phase 213 trials · 1 met primary · 1 missed
Phase 2 NCT05402891 Jun 2022 → Sep 2024 classic familial adenomatous polyposis Academic Medical Center - University of Amsterdam Completed No outcome recorded
Phase 2 NCT02999022 Jul 2017 → Dec 2024 — Sunnybrook Health Sciences Centre Unknown No outcome recorded
Phase 2 NCT02862210 Jan 2017 → Nov 2022 frontotemporal dementia Columbia University Completed No outcome recorded
Phase 2 NCT03204500 May 2016 → Apr 2019 sporadic amyotrophic lateral sclerosis El Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez Completed No outcome recorded
Phase 2 NCT01855594 May 2013 → Jun 2015 neuralgia, neuropathy, painful, spinal cord injury China Spinal Cord Injury Network Completed No outcome recorded
Phase 2 NCT01105702 May 2010 → Apr 2014 brain cancer NYU Langone Health Terminated No outcome recorded Stop: Enrollment
Phase 2 NCT00998634 Oct 2009 → Nov 2012 spinocerebellar ataxia type 2 Federico II University Completed No outcome recorded
Phase 2 NCT00997672 Oct 2009 → Aug 2011 multiple system atrophy Federico II University Terminated No outcome recorded
Phase 2 NCT00750061 Aug 2008 → May 2010 spinal cord injury China Spinal Cord Injury Network Completed Missed primary
Phase 2 NCT00790582 May 2008 → Mar 2010 amyotrophic lateral sclerosis Forbes Norris MDA/ALS Research Center Completed No outcome recorded
Phase 2/32 trials · 1 missed
Phase 2/3 NCT06789783 May 2024 → Sep 2025 overdue Cornelia de Lange syndrome University of Milan Recruiting No outcome recorded
Phase 2/3 NCT01096082 May 2011 → Dec 2012 Machado-Joseph disease Hospital de Clinicas de Porto Alegre Completed Missed primary
Phase 39 trials
Phase 3 NCT04623398 Feb 2022 → Aug 2024 autism spectrum disorder Assistance Publique - Hôpitaux de Paris Completed No outcome recorded
Phase 3 NCT05126238 Nov 2021 → May 2025 carotid stenosis Negovsky Reanimatology Research Institute Terminated No outcome recorded
Phase 3 NCT06008249 Aug 2021 → Sep 2025 amyotrophic lateral sclerosis TRICALS Foundation Terminated No outcome recorded
Phase 3 NCT05221593 Aug 2020 → Apr 2022 neutropenia Al-Azhar University Completed No outcome recorded
Phase 3 NCT01112813 Apr 2010 → Jul 2017 ischemic stroke Sunnybrook Health Sciences Centre Completed No outcome recorded
Phase 3 NCT00422331 Jan → Dec 2007 manic bipolar affective disorder JDS Pharmaceuticals Unknown No outcome recorded
Phase 3 NCT00276965 Sep 2006 → Mar 2012 bipolar II disorder, depressive disorder Lindner Center of HOPE Completed No outcome recorded
Phase 3 NCT00485680 Dec 2003 → Jun 2005 bipolar disorder Eli Lilly and Company Completed No outcome recorded
Phase 3 NCT00057681 Feb 2003 → Dec 2008 bipolar disorder Washington University School of Medicine Completed Mixed
Phase 48 trials · 1 missed
Phase 4 NCT05593627 Jul 2023 → Dec 2025 overdue cardiac valvular defect China Medical University, China Recruiting No outcome recorded
Phase 4 NCT04826510 Nov 2020 → Jun 2021 depressive disorder Shanghai Mental Health Center Unknown No outcome recorded
Phase 4 NCT04479566 Nov 2020 → Jan 2022 — China Medical University, China Completed No outcome recorded
Phase 4 NCT01669369 Jan 2013 → Dec 2023 osteosarcoma Sun Yat-sen University Unknown No outcome recorded
Phase 4 NCT02918097 May 2010 → Nov 2014 bipolar disorder Federal University of Rio Grande do Sul Completed No outcome recorded
Phase 4 NCT00667745 Apr 2008 → Mar 2010 bipolar disorder National Institute of Mental Health (NIMH) Completed Missed primary
Phase 4 NCT00202306 Nov 2001 → Dec 2006 bipolar disorder, schizophrenia Melbourne Health Completed No outcome recorded
Phase 4 NCT00177567 Jul 2001 → Jan 2004 bipolar disorder University of Pittsburgh Completed No outcome recorded
Phase not applicable1 trial
— NCT00408681 Jun 2006 → Nov 2010 Burkitt lymphoma, Hodgkins lymphoma, MALT lymphoma, acute myeloid leukemia with 11q23 abnormalities +33 Fred Hutchinson Cancer Center Completed No outcome recorded
Comparator or background therapy11 trials
Phase 1/2 NCT01354483 Background Sep 2011 → Sep 2013 spinal cord injury China Spinal Cord Injury Network Completed No outcome recorded
Phase 1/2 NCT00240110 Background Mar 2006 → Mar 2014 bipolar disorder, cocaine dependence University of Miami Completed No outcome recorded
Phase 2 NCT01189812 Comparator Mar 2010 → Jan 2011 borderline personality disorder, dysthymic disorder, major depressive disorder Columbia Northwest Pharmaceuticals Completed No outcome recorded
Phase 2/3 NCT00818389 Comparator Jan → Oct 2009 amyotrophic lateral sclerosis Massachusetts General Hospital Terminated No outcome recorded
Phase 3 NCT00789854 Comparator Nov 2008 → Aug 2009 major depressive disorder AstraZeneca Completed No outcome recorded

News releases announcing trial results or a regulatory action · 3

DateIssuerRelease
2026-04-07 Alzamend Neuro, Inc. Results Alzamend Neuro Reports Encouraging Pharmacodynamic Data from Phase II Clinical Trial of AL001 "Lithium in Brain" Study in a Trial Conducted at Massachusetts General Hospital alzamend.com ↗
Across multiple brain regions, AL001 and lithium carbonate appeared to trend in opposite directions in brain chemistry measures, suggesting that AL001 may interact with the brain in a distinct manner and generate a lower neurochemical footprint than lithium carbonate
2024-12-18 Alzamend Neuro, Inc. Results Alzamend Neuro to Present Non-Clinical Data Update at the Society of Toxicology 2025 Annual Meeting and ToxExpo alzamend.com ↗
2024-11-19 Alzamend Neuro, Inc. Results Alzamend Neuro Announces Full Data Set from its Nonclinical Study: Comparing Brain and Plasma Lithium Exposures between AL001 and Lithium Carbonate in Alzheimer’s Transgenic Mice alzamend.com ↗
Alzamend Neuro, Inc. (Nasdaq: ALZN) (“ Alzamend ”), a clinical-stage biopharmaceutical company focused on developing novel products for the treatment of Alzheimer’s disease (“ Alzheimer’s ”), bipolar disorder (“ BD ”), major depressive disorder (“ MDD ”) and post-traumatic stress disorder (“ PTSD ”), today announced that it has finished analyzing the final full data set from a nonclinical study comparing brain and plasma lithium exposures between AL001 and lithium carbonate in Alzheimer’s transgenic mice.

All press releases naming this drug 22 releases

DateIssuerRelease

Evidence & citations 4 cited values

Every value below carries the sentence it was read from. 60 sources stand behind the page.

FieldValueCited text
Known as lithium carbonate “we propose a clinical trial to study the security and efficacy of lithium carbonate targeting the patients with TBR1-related disorders” NCT06776848 ↗
59

“Blue pills ( 200 mg of magnesium valproate ) and white pills ( 300 mg of lithium carbonate) are administered orally with meals.” NCT03204500 ↗

“will be treated with lithium carbonate orally achieving a serum level of 0.2-0.4 mmol/l between month 6 and 12.” PMID 35962368 ↗ Aug 2022

“Subjects will receive 300 mg of lithium carbonate at 22.00 the day before the renal function tests” NCT01146288 ↗

“lithium carbonate” NCT00986128 ↗

NCT00818389 ↗

NCT00485680 ↗

NCT01855594 ↗

NCT00202306 ↗

NCT04222816 ↗

NCT06789783 ↗

Show 49 more sources

Known as lithium “The primary goal of this investigation is to examine the additive prophylactic potential of an individual psychotherapy based on interpersonal and social rhythm principles in...” NCT00000369 ↗
2

“To test whether low-dose lithium carbonate ameliorates disability accumulation in progressive MS, patients with progressive MS were randomly assigned to take lithium in either...” NCT01259388 ↗

“lithium carbonate (lithium)” NCT01754883 ↗

Action Inhibit “Recent evidence points to the inhibition of the enzyme glycogen synthase kinase-3beta (GSK3) as one of its mechanisms of action.” NCT01055392 ↗
Route Oral “oral lithium treatments” NCT00431171 ↗