drugset / Trial / NCT00986128
A Pharmacokinetic Study of Lithium Before and During Topiramate Dosing in Bipolar Disorder Patients
Non-randomizedSingle-groupOpen-labelTreatment
Summary
The purpose of this study is to determine the initial (after 1-week of maintenance dosing) and extended (after 3-weeks of maintenance dosing) effect of topiramate, at doses up to 600 mg/day, on the steady-state pharmacokinetics (absorption, distribution and excretion of the drug by the body) of lithium carbonate in patients with bipolar disorders.
Timeline
- Start
- 2001-03
- Primary completion
- —
- Completion
- 2002-10
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Lithium Carbonate | Unknown | — | — |
| Subject | Topiramate | Small molecule | 100 mg | Oral |
| Subject | Topiramate | Small molecule | 300 mg | Oral |