drugset / Trial / NCT05230472
Effect of Statin Therapy on Mortality in Patients With Ventilator Associated Pneumonia
RandomizedParallel-groupTriple-blindPrevention
Summary
Statins with their powerful anti-inflammatory, immunomodulatory, and antioxidant properties make them candidate members to be used in the management of sepsis and different types of infections including pneumonia. This study aims to determine whether adjunctive statin therapy decreased day- 28 mortality among ICU patients with ventilator-associated pneumonia (VAP) \& number of ventilator-free days (after successful weaning) between day 1 and both day 28.
Timeline
- Start
- 2021-01-01
- Primary completion
- 2021-12-20
- Completion
- 2022-02-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Simvastatin | Small molecule | 60 mg | Other |