drugset / Trial / NCT05230472

Effect of Statin Therapy on Mortality in Patients With Ventilator Associated Pneumonia

NCT05230472

Phase 4 Completed 161 enrolled Ain Shams University
RandomizedParallel-groupTriple-blindPrevention

Summary

Statins with their powerful anti-inflammatory, immunomodulatory, and antioxidant properties make them candidate members to be used in the management of sepsis and different types of infections including pneumonia. This study aims to determine whether adjunctive statin therapy decreased day- 28 mortality among ICU patients with ventilator-associated pneumonia (VAP) \& number of ventilator-free days (after successful weaning) between day 1 and both day 28.

Timeline

Start
2021-01-01
Primary completion
2021-12-20
Completion
2022-02-01

Drugs

EvaluationDrugModalityDoseRoute
Comparator Simvastatin Small molecule 60 mg Other