Lidocaine VS Hemodynamic, Metabolic and Hormonal Response

Summary

Intravenous lidocaine - a potent local anesthetic with analgesic and anti- inflammatory properties has been shown to be an effective adjunct that reduces intra and postoperative opioid consumption and facilitates pain management in adults. In children population promising but limited evidence is available. The study has been planned to evaluate the efficacy of continuous intravenous infusion of lidocaine in alleviation of hemodynamic reaction to tracheal intubation, as well as metabolic and hormonal response to laparoscopic procedure in children.

Timeline

Start

2022-03-12

Primary completion

2023-08-08

Completion

2023-08-08

Publications

• Background Qi DY, Wang K, Zhang H, Du BX, Xu FY, Wang L, Zou Z, Shi XY. Efficacy of intravenous lidocaine versus placebo on attenuating cardiovascular response to laryngoscopy and tracheal intubation: a systematic review of randomized controlled trials. Minerva Anestesiol. 2013 Dec;79(12):1423-35. Epub 2013 Jul 9.
• Background El-Deeb A, El-Morsy GZ, Ghanem AAA, Elsharkawy AA, Elmetwally AS. The effects of intravenous lidocaine infusion on hospital stay after major abdominal pediatric surgery. A randomized double-blinded study. Egypt J Anaesth. 2013;29(3):225-230, doi: 10.1016/j.egja.2013.02.005.
• Background Kaszynski M, Lewandowska D, Sawicki P, Wojcieszak P, Pagowska-Klimek I. Efficacy of intravenous lidocaine infusions for pain relief in children undergoing laparoscopic appendectomy: a randomized controlled trial. BMC Anesthesiol. 2021 Jan 5;21(1):2. doi: 10.1186/s12871-020-01218-0.
• Kaszynski M, Stankiewicz B, Kalicka A, Mikolap K, Olszanecka M, Rybka Z, Witt P, Darowski M, Pagowska-Klimek I. Comparison of Opioid Consumption During Paediatric Anaesthesia with and Without a Mandatory Protocol: A Retrospective Cohort Study. J Clin Med. 2025 Oct 22;14(21):7481. doi: 10.3390/jcm14217481.
• Kaszynski M, Kuczerowska A, Pietrzyk J, Sawicki P, Witt P, Stankiewicz B, Darowski M, Pagowska-Klimek I. Influence of intravenous lidocaine infusion on haemodynamic response to tracheal intubation and metabolic-hormonal responses during laparoscopic procedures in children: a randomised controlled trial. BMC Anesthesiol. 2025 Jan 10;25(1):23. doi: 10.1186/s12871-024-02885-z.

Drugs

Indications