Hypersensitivity to Opening of ATP-Sensitive Potassium Channels in Post-Traumatic Headache

Completed 21 enrolled Danish Headache Center

RandomizedCrossoverQuadruple-blindBasic science

Summary

The aim is to investigate whether opening of ATP-sensitive potassium (KATP) channels induces headache with migraine-like features in people with persistent post-traumatic headache (PTH) attributed to mild traumatic brain injury (mTBI).

Timeline

Start: 2022-03-21
Primary completion: 2022-07-07
Completion: 2022-07-07

Publications

Al-Khazali HM, Christensen RH, Dodick DW, Chaudhry BA, Burstein R, Ashina H. Hypersensitivity to opening of ATP-sensitive potassium channels in post-traumatic headache. Cephalalgia. 2023 Nov;43(11):3331024231210930. doi: 10.1177/03331024231210930.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Levcromakalim	Small molecule	0.05 mg	Intravenous

Indications

No indication recorded.