Dosing of Ketorolac Impacts Post-cesarean paiN manaGemenet (KING)

Phase 4 Completed 92 enrolled Ohio State University

RandomizedParallel-groupSingle-blindTreatment

Summary

This is a randomized controlled single blinded trial to compare the morphine milligram equivalents (MME) use in the first 24 hours postoperatively after cesarean section in patients receiving a single dose of 30 mg intravenous ketorolac vs. 60 mg intravenous ketorolac in the operating room after the end of surgery.

Timeline

Start: 2022-06-08
Primary completion: 2023-11-30
Completion: 2023-11-30

Publications

Eid J, Caplan M, Goel N, Poirier MV, Montaine-O'Brien S, Rood KM, Costantine MM. Two Perioperative Ketorolac Dosing Regimens After Cesarean Delivery and Opioid Use: A Randomized Controlled Trial. O G Open. 2026 Mar 26;3(2):e159. doi: 10.1097/og9.0000000000000159. eCollection 2026 Apr.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Ketorolac	Other / unclassified	30 mg	Intravenous
Subject	Ketorolac	Other / unclassified	60 mg	Intravenous

Indications

No indication recorded.