A Clinical Study of TAB006 in Patients With Previously Treated, Advanced Malignancies

Summary

The primary objective is to assess the safety and tolerability of TAB006 as monotherapy and in combination with toripalimab in subjects with selected advanced solid malignancies, including lymphoma, and to evaluate the recommended Phase 2 dose. The secondary objectives are to: 1) describe the pharmacokinetic (PK) profile of TAB006 monotherapy and in combination with toripalimab and to describe the PK profile of toripalimab when administered with TAB006, 2) evaluate antitumor activity of TAB006 monotherapy and in combination with toripalimab; and 3) determine the immunogenicity of TAB006 monotherapy and in combination with toripalimab and to determine the immunogenicity of toripalimab when administered with TAB006.

Timeline

Start

2022-03-15

Primary completion

2026-09

Completion

2027-01

Outcome

Outcome not reported

Stopped: “transfer the study to another sponser”

Drugs

Indications