drugset / Trial / NCT05273775
A Pharmacokinetic Study to Evaluate the Drug Interaction Between HRS5091 and Probe Drugs in Healthy Volunteers
NaSingle-groupOpen-labelBasic science
Summary
This is a drug-drug interaction study conducted in healthy volunteers to evaluate the effect of HRS5091 on CYP3A4, CYP2C9, CYP2C19, P-gp, BCRP and OATP1B1, using midazolam, s-warfarin, omeprazole, digoxin and rosuvastatin as probe drugs.
Timeline
- Start
- 2022-04-29
- Primary completion
- 2022-06-23
- Completion
- 2022-06-23
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Digoxin | Other / unclassified | — | — |
| Subject | HRS5091 | Unknown | — | — |
| Subject | Midazolam | Small molecule | — | — |
| Subject | Omeprazole | Other / unclassified | — | — |
| Subject | Rosuvastatin | Small molecule | — | — |
| Subject | Warfarin | Small molecule | — | — |
| Background | Vitamin K | Unknown | — | — |