drugset / Trial / NCT05331911
Impact of Propofol-Based Total Intravenous Anesthesia Versus Anesthesia With Sevoflurane on Long-term Outcomes With Patients Undergoing Elective Excision of Primary Liver Tumors
Phase 4
Recruiting
500 enrolled
Kaohsiung Medical University Chung-Ho Memorial Hospital
Tri-Service General Hospital (TSGH) · collab
RandomizedParallel-groupTriple-blindTreatment
Summary
This is a two-arm, parallel-group randomized clinical trial. Routine perioperative care would be performed in volunteers with primary Hepatocellular carcinoma. The study will enroll approximately 500 volunteers to compare the progression-free or overall survival in patients undergoing elective partial hepatectomy for primary liver tumors between propofol and sevoflurane for the maintenance of anesthesia.
Timeline
- Start
- 2022-04-26
- Primary completion
- 2026-12-31
- Completion
- 2027-03-31
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Propofol | Small molecule | 2 ug/ml | Intravenous |
| Subject | Propofol | Small molecule | 4 ug/ml | Intravenous |
| Subject | Sevoflurane | Other / unclassified | 1 % | Inhaled |
| Subject | Sevoflurane | Other / unclassified | 3 % | Inhaled |