drugset / Trial / NCT05340803

Sedation of Ventilated Traumatic Brain Injury Patients With Midazolam Alone Versus Combination With Dexmedetomidine or Magnesium Sulfate; Monitored by Ultrasonograghic Optic Nerve Sheath Diameter

NCT05340803

Phase 3 Unknown 108 enrolled Assiut University
RandomizedParallel-groupDouble-blindSupportive care

Summary

In TBI, there is a strong correlation between increased ICP and bad outcome. So, appropriate monitoring can be the gold standard in management of TBI. ICP can be measured by invasive and noninvasive methds. One of these noninvasive methods is bedside measurement of optic nerve sheath diameter (ONSD) by ocular ultrasonography

Timeline

Start
2022-11-01
Primary completion
2025-01-01
Completion
2025-12-01

Drugs

EvaluationDrugModalityDoseRoute
Comparator Dexmedetomidine Other / unclassified
Comparator Magnesium Sulfate Other / unclassified
Comparator Midazolam Small molecule