drugset / Trial / NCT05362799

Different Induction Protocols in PCOS After Clomiphene Citrate Failed Pregnancy in Non-IVF Cycles

NCT05362799

Phase 4 Unknown 176 enrolled Menoufia University
RandomizedParallel-groupOpen-labelTreatment

Summary

The aim of this study will be to compare between 4 different induction protocols in women who: 1. Failed to achieve ovulation after clomiphene citrate treatment at a dose of 150mg daily (if the patient can tolerate this dose) for 5 days for 3 cycles or only 100 mg daily for the same duration (if she can't tolerate higher dose) 2. Failed to achieve pregnancy after 3 cycles of ultrasound indicated ovulation with clomiphene citrate treatment at a dose of 100mg or 150mg daily. All induction protocols will be carried out in non-IVF cycles, and continued for 3 cycles or until pregnancy whichever will be earlier.

Timeline

Start
2022-06-01
Primary completion
2023-12-31
Completion
2023-12-31

Drugs

EvaluationDrugModalityDoseRoute
Comparator Letrozole Other / unclassified 2.5 mg
Comparator Metformin Small molecule 500 mg
Comparator Uroffollitropin Unknown 75 iu Subcutaneous

Indications