drugset / Trial / NCT05365477
Empiric Versus Selective Prevention Strategies for Kidney Stone Disease
RandomizedParallel-groupQuadruple-blindPrevention
Summary
The aims of this study are to 1) Conduct a randomized clinical trial of selective versus empiric diet plus pharmacologic therapy in high-risk stone formers and 2) Determine adverse effects from, and adherence to selective and empiric strategies.
Timeline
- Start
- 2022-08-04
- Primary completion
- 2025-09-26
- Completion
- 2026-03-31
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Allopurinol | Small molecule | 300 mg | — |
| Comparator | Indapamide | Small molecule | 1.25 mg | — |
| Comparator | Indapamide | Small molecule | 2.5 mg | — |
| Comparator | POTASSIUM CITRATE ANHYDROUS | Small molecule | 15 meq | — |
| Comparator | POTASSIUM CITRATE ANHYDROUS | Small molecule | 30 meq | — |
| Subject | Potassium Chloride | Small molecule | 20 meq | — |